IM #57

Isaiah McGuire

Defensive End · Missouri

A fourth-round Missouri pass rusher who has steadily carved out a rotational role on Cleveland's defensive line.

Isaiah McGuire arrived in Cleveland as a long, athletic edge piece out of Missouri and has spent his early career grinding for snaps behind the Browns' veteran front. He is not a household name, but he is the kind of developmental rusher teams count on to add depth and disruption off the bench.

★ Second-team All-SEC (2022)

★ 13.5 sacks over final two Missouri seasons

★ Fourth-round pick, 2023 NFL Draft (No. 126 overall)

Path to the league

McGuire, a Tulsa, Oklahoma native, became a two-year starter at Missouri and closed his college career with 13.5 sacks over his final two seasons. He led the Tigers with six sacks in 2021 and 7.5 in 2022, earning second-team All-SEC honors, before the Browns drafted him in the fourth round (126th overall) of the 2023 NFL Draft.

Career highlights

At 6-foot-4 and 268 pounds, McGuire was pegged by Cleveland's personnel department as a long defensive end with pass-rush upside. He broke into the Browns' regular rotation during his second season, appearing in 16 games in 2024 with three starts, racking up 34 tackles, three forced fumbles and 2.5 sacks.

2025 season recap

McGuire built on that progress in 2025, recording roughly 29 tackles and finishing with 2.5 to 3 sacks and a forced fumble as a regular contributor in Cleveland's defensive end rotation. He continued to develop as a run-defending complement to the Browns' pass rushers rather than an every-down starter.