NFL 2026
Game Recap October 12, 2026 · Touchdown Week Staff

Lions Rout Cardinals 45-21 in Week 5

Detroit Lions 45, Arizona Cardinals 21 at State Farm Stadium. Jared Goff went 19 of 30 for 271 yards with 3 touchdowns.

The Detroit Lions beat the Arizona Cardinals 45-21 on Sunday, October 11 at State Farm Stadium in Glendale, AZ. The Cardinals are 1-4 and the Lions are 3-2.

45-21 Final
Box score, scoring plays & game leaders →

How did the scoring go?

The Cardinals led 7-0 after the first quarter, the Lions led 24-7 at halftime, and the Lions led 38-14 after three quarters. The Cardinals scored first on a Teagan Quitoriano 2-yard pass from Jacoby Brissett with 5:06 left in the first quarter. The final points came on a Trey McBride 9-yard pass from Jacoby Brissett for the Cardinals in the fourth quarter.

Who led the way?

For the Lions, Jared Goff went 19 of 30 for 271 yards with 3 touchdowns. Jahmyr Gibbs had 25 carries for 151 yards and 2 touchdowns, and Sam LaPorta caught 5 passes for 88 yards with 1 touchdown. For the Cardinals, Jacoby Brissett went 29 of 47 for 292 yards with 3 touchdowns and 1 interception. Jeremiyah Love had 12 carries for 22 yards, and Kendrick Bourne caught 5 passes for 70 yards.

What do the team stats show?

The Lions outgained the Cardinals 412 to 327 in total yards. The Cardinals turned the ball over once while the Lions had no turnovers. On third down, the Lions went 4-13 and the Cardinals went 8-18. Time of possession was 29:49 for the Lions and 30:11 for the Cardinals.

How did the AI prediction hold up?

Touchdown Week's AI Prediction had the Lions winning, with a projected score of Lions 31, Cardinals 24 at medium confidence. The pick was right on the winner, with the projected margin off by 17 points. With the margin off by 17. Jahmyr Gibbs ran for 151 yards and two touchdowns, Jared Goff threw three scoring passes, and Detroit led 38-14 after three quarters. The total of 66 beat the projected 55, as the preview expected.

Sources

  • ESPN: Detroit Lions at Arizona Cardinals box score

Cardinals & Lions betting odds

Super Bowl futures, win totals & where to bet

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Published October 12, 2026 Touchdown Week Staff