Week 3: Cardinals Visit 49ers After a Week of Opposite Directions
The Arizona Cardinals visit the San Francisco 49ers on Sunday, September 27. Arizona is 1-1 after a 31-7 home loss to Seattle in which it gained 151 yards and Jacoby Brissett threw for 95, and cornerback Will Johnson could miss the season with a neck injury. San Francisco is 2-0 after a 35-13 win over Miami in which Brock Purdy went 20 of 22 for 287 yards; receiver De'Zhaun Stribling is out about 10 weeks and tight end Jake Tonges is done for the season.
Purdy's start
Twenty of 22 against Miami and three touchdowns against the Rams; the 49ers have scored 62 points.
Arizona's Week 1 was the outlier
The Cardinals beat the Chargers in Week 1's biggest upset, then managed 151 yards against Seattle.
San Francisco's receiver depth
Stribling and Pearsall are out, Christian Kirk cannot return until after Week 4; George Kittle and Christian McCaffrey are the offense.
AI Prediction
Cardinals 
49ers San Francisco is the most efficient offense in the league through two weeks
Purdy has 12 incompletions in two games; Arizona just allowed 381 yards to Seattle.
Arizona's offense has one good game
Twenty-six points in Los Angeles, seven at home, and now a road trip to a defense that held Miami to six through three quarters.
The Cardinals' secondary lost Johnson
Starling Thomas steps in against Kittle and McCaffrey; the projection is two scores.
The second of the week's two widest leans. Arizona's win in Los Angeles keeps the model from going higher.
49ers Leaders
Cardinals Leaders
Team Stats
| Cardinals | Stat | 49ers |
|---|---|---|
| 16.5 | Points Per Game | 31.0 |
| 279.0 | Total Yards | 380.5 |
| 186.0 | Yards Passing | 246.0 |
| 93.0 | Yards Rushing | 134.5 |
| 22.5 | Points Allowed Per Game | 10.0 |
| 343.5 | Yards Allowed | 294.5 |
| 222.0 | Pass Yards Allowed | 182.5 |
| 121.5 | Rush Yards Allowed | 112.0 |
Venue
Closing Line
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49ers Injuries