Week 2: Colts Visit Chiefs on Sunday Night After Mahomes' Clean Return
The Indianapolis Colts visit the Kansas City Chiefs on Sunday night, September 20. Patrick Mahomes threw two touchdowns and ran for another in a 31-10 win over Denver in his first game back from knee surgery, and Kenneth Walker III ran for 173 yards in his Chiefs debut. Left tackle Josh Simmons remains out with a back injury, so undrafted rookie Kahlil Benson starts again. Indianapolis managed 251 yards in a 41-23 loss at Baltimore, with Daniel Jones throwing an interception in his first game back from an Achilles tear and the offense gaining 23 yards across four drives after an opening touchdown; Alec Pierce is expected to play after a hand scare.
Kansas City on a short week after Monday night
Six days between games is the only structural edge for Indianapolis, which had a full week.
Walker's debut changed Kansas City's offense
A 173-yard rushing day gave Mahomes something the 6-11 team of 2025 rarely had: a run game that forced Denver out of its coverage shells.
Jones needs a bounce-back
Indianapolis called the Baltimore loss a wake-up call; the fourth-lowest yardage total of Shane Steichen's tenure came against a defense with a comparable pass rush to Kansas City's.
AI Prediction
Colts 
Chiefs Mahomes healthy at Arrowhead in prime time
The opener answered the biggest question about Kansas City's season, and a run game to lean on makes the offense more complete than last year's.
Indianapolis showed little on offense in Week 1
One long drive and then 23 yards on four possessions against Baltimore; Jones' rust is the Colts' main problem.
Kansas City's short week and rookie left tackle
Benson held up against Denver, but a second straight start on short rest against Indianapolis' edge rushers is why the margin stays at a touchdown.
A high-confidence home pick that matches the sportsbook favorite. The Colts' offense would need a very different game from its Week 1 showing to make this close.
Chiefs Leaders
Colts Leaders
Team Stats
| Colts | Stat | Chiefs |
|---|---|---|
| 23.0 | Points Per Game | 31.0 |
| 268.0 | Total Yards | 392.0 |
| 166.0 | Yards Passing | 172.0 |
| 102.0 | Yards Rushing | 220.0 |
| 41.0 | Points Allowed Per Game | 10.0 |
| 526.0 | Yards Allowed | 192.0 |
| 324.0 | Pass Yards Allowed | 131.0 |
| 202.0 | Rush Yards Allowed | 61.0 |
Venue
Closing Line
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Chiefs Injuries