Week 2: Rebuilding Dolphins Visit 49ers in Week's Largest Spread
The Miami Dolphins visit the San Francisco 49ers on Sunday, September 20, as double-digit underdogs, the largest spread of Week 2 at 12.5 to 13.5 depending on the book. San Francisco beat the Rams 27-7 in Melbourne with three Brock Purdy touchdown passes and the final 24 points of the game, and has extra rest after playing on Thursday. Malik Willis took five sacks in Miami's 27-13 loss at Las Vegas, with the Dolphins going 2 of 10 on third down. San Francisco lost tight end Jake Tonges to an MCL injury and rookie receiver De'Zhaun Stribling for at least a month with an ankle sprain.
Willis under pressure again
Five sacks against the Raiders, and now Nick Bosa and Fred Warner, both back from season-ending injuries, at Levi's Stadium.
San Francisco's second-half surge
The 49ers turned a 7-3 deficit into 27-7 in Australia behind Purdy, Mike Evans, Deebo Samuel and Christian McCaffrey's 88 yards from scrimmage.
Miami's rebuild is showing
With Tagovailoa, Hill and Waddle gone, the Dolphins were 1 of 3 in the red zone and outgained by 46 yards by a Raiders team that spent the offseason rebuilding too.
AI Prediction
Dolphins 
49ers The largest talent gap of the week
San Francisco's opener was a complete performance against a Rams team favored to win the conference; Miami's was a five-sack loss to a rebuilding team.
Rest and home field compound it
Extra days after the Thursday game in Australia, a home opener, and a defense that has its two best players healthy.
Tonges and Stribling matter at the margins only
Losing depth at tight end and receiver trims the projected total but not the outcome.
The model's most confident pick of Week 2 and roughly in line with the sportsbook spread. Miami's offense has not yet shown it can sustain drives against a competent defense.
49ers Leaders
Dolphins Leaders
Team Stats
| Dolphins | Stat | 49ers |
|---|---|---|
| 13.0 | Points Per Game | 27.0 |
| 259.0 | Total Yards | 379.0 |
| 185.0 | Yards Passing | 205.0 |
| 74.0 | Yards Rushing | 174.0 |
| 27.0 | Points Allowed Per Game | 7.0 |
| 290.0 | Yards Allowed | 290.0 |
| 160.0 | Pass Yards Allowed | 168.0 |
| 130.0 | Rush Yards Allowed | 122.0 |
Venue
Closing Line
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49ers Injuries